In 1887, a vampire wakes up and seeks to quench his thirst for blood. Brave men and women ally to destroy him – but to do so, they will have to thwart the plot of Renfield, his faithful servant.

Nosferatu is a card game mixing tactics, bluffing, and team play, with the vampire and Renfield facing off against the vampire hunters. At the start of the game, everyone knows who Renfeld is, and Renfield knows which of the hunters is actually a vampire (as he chooses how to distribute the character cards), but the vampire's identity is hidden from everyone else. The hunters must identify the vampire and kill him with the ancestral stake before he can play five bite cards; if the hunters accidentally stake one of their own, then demoralized and weakened they lose the game.